Protein kinase C alpha is a proposed therapeutic target in androgen-independent PCa (O’Brian, 1998); therefore, it is important to understand how elevated PKCα expression as observed in PCa influences downstream targets which are also implicated in tumourigenesis; for example, phospholipase D (PLD) (Cockcroft, 2001; Foster, 2009). Here, PRKCA is linked to posterior cortical atrophy.