Human colon adenomas, a premalignant tumor in which p53-mediated cellular senescence is pathologically induced in vivo[37,38], were shown to express higher levels of Siah1 and lower levels of TRF2 than normal non-senescent tissues [27], recapitulating the expression profile observed in senescent fibroblasts in vitro. Here, SIAH1 is linked to colon adenoma.