Moreover, our study also revealed that these two genes were differentially expressed in esophageal and prostate cancer cell lines [5,8] and that benzo[a]pyrene diol epoxide (BPDE) reduced RRIG1 expression but did not alter SH3GLB2 mRNA levels in esophageal cancer cell lines (our unpublished data). The gene discussed is SH3GLB2; the disease is esophageal cancer.