TIMP1 and infection: On the other hand, the secretion profile of TIMP-1,TIMP-2, and TIMP-3 did not change significantly under any infection modality; this result contrasts with previous evidence indicating that stimulating chorioamniotic membranes with LPS induces a significant decrease of TIMP-2 [24,25,40,41], but which agrees with evidence demonstrating that intrauterine infection in pregnant rhesus monkeys induces a significant diminution of TIMP-1 [16].