MEN1 and neoplasm: Although, pathogenetic mutations of glutamic acid either to lysine (p.E45K) or glykine (p.E45G) or alanine (p.E45A), have been previously described [37], the close proximity of this amino acid (amino acid 45) to the area (amino acids 1-40) of menin molecule responsive for Menin-JunD interaction, poses a possible explanation of the present tumorgenesis by disrupting Menin-JunD interaction, finally affecting the tumor suppression function.