In the central nervous system (CNS), LRP1 is highly expressed in neurons and plays critical roles in lipoprotein metabolism, neurotransmission, synaptic plasticity, cell survival, and clearance of the amyloid-β (Aβ) peptide, critical in the pathogenesis of Alzheimer's disease (AD) [5]–[7]. The gene discussed is LRP1; the disease is Alzheimer disease.