It would be interesting to study the interaction between TL1A and other known pro-fibrogenic factors such as transforming growth factor beta 1 (TGF-β1) and insulin-like growth factor 1 (IGF-1) using the chronic 2,4,6-trinitrobenzensulfonic acid (TNBS) colonic injury model which causes both colitis and intestinal fibrosis [29], [30], [31]. The gene discussed is TNFSF15; the disease is colitis.