Supporting this notion, elevated ratios of tau/Aβ42 and p-tau181/Aβ42 (consistent with the presence of amyloid plaques and neurodegeneration) have been associated with increased risk of converting from cognitive normalcy to mild cognitive impairment or dementia [9], [15], and with increased rate of cognitive decline among those with very mild dementia [16]. The gene discussed is MAPT; the disease is Mental deterioration.