Stepwise logistic regression analyses indicated that, among the nine biomarkers under consideration, YKL-40, NrCAM and tau yielded the highest AUC (0.896) in discriminating cognitive normalcy (CDR 0) from very mild to mild dementia (CDR>0) (Figure 6C, Table 3); for discriminating mild dementia (CDR 1) from CDR<1, carnosinase I, chromogranin A and tau yielded the highest AUC (0.876) (Figure 6D, Table 4). The gene discussed is CHGA; the disease is dementia.