To evaluate and compare the potential of the validated candidate biomarkers and Aβ42, tau, and p-tau181 for identifying either very mild to mild dementia (combined CDR 0.5 and CDR 1) or mild dementia (CDR 1), ROC curves and AUCs were calculated for each biomarker using data from the ‘validation’ cohort (Figure 6A, B, Tables 3, 4). Here, MAPT is linked to dementia.