We found that transplantation of CD133high/membrane E-cadherinlow/intermediate/cytoplasmic E-cadherin+/Tie2− resulted in tumors consisting of membrane E-cadherinhigh/Tie2-positive cells, indicating that tumor growth in vivo is driven by E/M-MP cells, which give rise to an E/M subset, with more dominant epithelial features (E/M-E), and subsequently to epithelial cells that lacked all mesenchymal and stem cell traits, and that had lost the ability to form tumors (when isolated in vitro in the form of clonal cultures) (Figure 9B, left scheme). This evidence concerns the gene CDH1 and neoplasm.