The formation of vasculogenic like networks has not been well understood; the processes involve several signaling molecules, including vascular endothelial (VE)-cadherin, erythropoietin-producing hepatocellular carcinoma-A2 (EphA2), phosphatidylinositol 3-kinase, focal adhesion kinase, matrix metalloproteinases and laminin 5 γ2-chain [38]. This evidence concerns the gene EPHA2 and hepatocellular carcinoma.