TGFBI and Cowden disease: An apparent genotype–phenotype correlation has emerged from these molecular studies, as four distinct heterozygous recurrent mutations in the transforming growth factor-β-induced gene (TGFBI) are associated with four specific phenotypes: p.R555W in granular corneal dystrophy type I (CDGG1), p.R124C in Lattice CD type I, p.R124H in granular CD (GCD) type II, and p.R555Q in Thiel-Behnke CD [3-5].