Next, we stably transfected SW480 cells with empty vector (SW480.Vector) and a vector expressing IKKβ mutant IKKβ-K44A (SW480.IKKβ-KA) [58], and examined the effects of inhibition of NF-κB activation on colon carcinoma cell sensitivity to TRAIL. This evidence concerns the gene TNFSF10 and colon carcinoma.