Since Abeta42 level is still low at this age of 3xTg-AD mice, many samples resulted in undetectable level: 2 out of 7 vehicle male, 6 out of 9 S14G-HN-treated male, none of vehicle female, and 5 out of 7 S14G-HN-treated female mice showed undetectable level of Abeta42. The gene discussed is APP; the disease is Alzheimer disease.