In this model, Abeta administration induces amnesia in rodents, decreases the number of cholinergic neurons [31], and reduces choline acetyltransferase activity [32], [33], [34], [35] Although the Abeta injection model is a simple and convenient model, the transgenic mouse model has some advantages, for instance production of multiple Abeta species through physiological process and amyloid plaque formation. The gene discussed is APP; the disease is amnesia.