In this study, we did not detect significant changes in phosphorylation of Tyr705 in STAT3 and Ser473 in Akt, while phosphorylation of Thr308 in Akt was significantly increased in S14G-HN-treaed 3xTg-AD mouse brains compared with control (Fig. 9). The gene discussed is STAT3; the disease is Alzheimer disease.