SPATA18 and cancer: Mieap expression was induced in response to DNA damage in various p53–wild-type cancer cell lines (LS174T-Cont, HepG2-Cont, and A549-Cont), but not in the corresponding p53-knockdown (KD) isogenic cell lines (LS174T-p53-KD, HepG2-p53-KD, and A549-p53-KD; Figure 1A).