Moreover, Mieap expression was not rescued by the overexpression of exogenous p53 in two p53-mutant cancer cell lines, H1299 (lung cancer) and U373MG (glioblastoma), or in the two p53–wild-type cancer cell lines (HCT116 and LC176) (Figure 2A). The gene discussed is SPATA18; the disease is glioblastoma.