SPATA18 and cancer: This was confirmed by the methylation sequences of two unmethylated cancer cell lines, LS174T (Figure 2D) and HepG2 (Figure S1A), and two methylated cancer cell lines, HCT116 (Figure 2D) and U373MG (Figure S1A), and by a demethylation experiment in the HCT116 cell line with azacytidine (Aza-C) treatment, which reactivated the transcription of Mieap (Figure S1B).