INS and type 2 diabetes mellitus: Pancreatic islet dysfunction of T2DM involves alterations in both insulin and glucagon secretion since proper concentrations of both are necessary for maintenance of glucose homeostasis.[9] Although there is ample indication that hyperglucagonemia plays a key role in the development of hyperglycemia in these patients, efforts to follow and correct this abnormality have been overshadowed by the emphasis on deficient insulin secretion and action.[7]