It is possible that the fruit extract improved the ability of the animals to utilize the external glucose load, a mechanism of action similar to that of the standard reference drug (tolbutamide), a sulfonylurea.[13] Sulfonylurea compounds produce hypoglycemia in normal animals by stimulating the pancreatic beta-cells to produce more insulin and by increasing the glycogen deposition in the liver, but are not effective in alloxan-induced diabetic animals because alloxan treatment causes a permanent destruction of the beta-cells.[14] In this study, a contrary result was obtained. The gene discussed is INS; the disease is Hypoglycemia.