Bakker et al described a patient with ACTH-dependent Cushing's syndrome whose clinical course was complicated by simultaneous infections with Pneumocystis carinii, Staphylococcus aureus, Candida albicans, Aspergillus fumigatus and Herpes simplex and which proved to be fatal8. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.