Our data also suggest that an important role of DAPK1 and other TS genes for fully and /or partially silencing through promoter CpG island hypermethylation in the development of NSCLC and the detection of aberrant hypermethylation on DAPK1 promoter from tumoral samples has potential clinical implications as a non-small lung tumor progression. Here, DAPK1 is linked to non-small cell lung carcinoma.