MKI67 and neoplasm: In subgroup analysis according to histological grade, patients with grade 1 tumours and moderate automated assessment of Ki-67 extent had a hazard ratio of 1.05 (95% CI 0.35-3.22) and patients with high automated assessment of Ki-67 extent a hazard ratio of 4.63 (95% CI 1.83-11.75), as compared to patients with low automated assessment of Ki-67 extent.