In a multivariate survival analysis, adjusted for tumour size, the number of positive lymph nodes, histological grade, method of detection and age at diagnosis, patients with a moderate automated assessment of Ki-67 extent of staining had a hazard ratio of 1.62 (95% CI 1.10-2.39) and those with high Ki-67 extent a hazard ratio of 1.73 (95% CI 1.19-2.51), compared to patients with low automated assessment of Ki-67 extent of staining (table 3). This evidence concerns the gene MKI67 and neoplasm.