RHOC and Familial prostate cancer: Examination of the TIC events in our study reveals several that involve cancer-associated genes, including the oncogenes E2F1, MAFG, MRAS, NTRK1, and RHOC. One TIC discovered in our study with particular relevance to prostate cancer is MSMB-NCOA4, for which we found two isoforms, e3-e2 and e2-e2, with the latter isoform supported by three ESTs.