For instance, established genetic and physical maps of the Otop1-containing region suggest an inverted gene order in the mouse and human genomes [14,15]; further, in these genomes, the Otop2-Otop3 gene tandem is physically clustered (head-to-tail) with the Usher syndrome (USH) subtype 1G gene (USH1G; also called SANS). This evidence concerns the gene USH1G and Usher syndrome.