The proposal that vagal tone is decreased, sympathetic tone is enhanced and increased production of IL-6, TNF-α, MIF and HMGB1 and decrease in plasma and tissue concentrations of AA, EPA and DHA and their products lipoxins, resolvins, protectins and maresins occurs in RA and lupus has important therapeutic implications. Here, HMGB1 is linked to systemic lupus erythematosus.