The proposal that vagal tone is decreased, sympathetic tone is enhanced and increased production of IL-6, TNF-α, MIF and HMGB1 and decrease in plasma and tissue concentrations of AA, EPA and DHA and their products lipoxins, resolvins, protectins and maresins occurs in RA and lupus has important therapeutic implications. This evidence concerns the gene CD59 and systemic lupus erythematosus.