TNF and rheumatoid arthritis: In this context, it will be interesting to study the effect of steroids, anti-TNF-α drugs, immunosuppressive drugs such as azathioprine, cyclophosphamide, cyclosporine, etc., on their ability to modulate alpha7nAChR and vagal tone and the formation of lipoxins, resolvins, protectins and maresins from various PUFAs and are thus, able to bring about some of their beneficial actions in RA and lupus.