IL1R1 and infection: The important role of IL1R1 in protecting the tooth and surrounding bone from polymicrobial infection (Streptococcus mutans, Streptococcus intermedius, Peptostreptococcus micros, Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum) was verified in vivo by using genetically modified IL1R1 knockout mice.