KCNMB1 and coronary artery disorder: This hypothesis was developed in the cardiologic field and data collected in the INVEST suggests variability in the large-conductance and voltage-dependant potassium channel beta 1 subunit gene, KCNMB1, is associated with the antihypertensive response to verapamil and also with cardiovascular adverse events in patients having hypertension with coronary arteries disease [12].