PD-linked mutations occur in the genes encoding α-Syn, Parkin, ubiquitin carboxy-terminal hydrolyase-L1 (UCH-L1), phosphatase and tensin homolog (PTEN)-induced putative kinase-1 (PINK1), DJ-1, and leucine-rich repeat kinase-2 (LRRK2). Here, PRKN is linked to Parkinson disease.