ALS-linked mutations occur in the genes (Table 4) encoding SOD1 (ALS1), Alsin (ALS2), senataxin (ALS4), fused in sarcoma (FUS, ALS6), vesicle associated membrane protein (VAMP/synaptobrevin)-associated protein B (VAPB, ALS8), p150 dynactin (DCTN1), and TAR-DNA binding protein (TADBP or TDP43) [5,408]. Here, TARDBP is linked to amyotrophic lateral sclerosis.