LRRK2 and Parkinson disease: Several missense mutations in the LRRK2 gene (PARK8) have been found, resulting in amino acid substitutions Tyr-1654→Cys, Arg-1396→Gly, Tyr-1699→Cys, Arg-1441→Cys, Ile-1122→Val, Ile-2020→Thr, that cause more commonly occurring autosomal dominant PD and possibly ‘sporadic’ PD [330,331].