However, a recent study using morpholino knockdown of the autophagy-related gene gabarap reported microcephaly and jaw defects in zebrafish morphants [69], whereas gabarap knockout mice are phenotypically normal [70], suggesting that further studies are needed to determine whether the roles of autophagy in mammalian development are conserved in non-mammalian vertebrates. The gene discussed is GABARAP; the disease is microcephaly.