One autopsy study of males over the age of 50, also conducted before PSA screening was implemented, indicated that the overall age-adjusted prevalence of latent prostate carcinoma was as high as 34.6% for whites and 36.9% for blacks in the United States[5], providing evidence that not all cases of prostate cancer have the same clinical aggressiveness. This evidence concerns the gene KLK3 and Familial prostate cancer.