Up-regulation of Gal-1 expression has been seen in a variety of carcinoma biopsies, particularly in tumor-associated stroma, and is associated with tumor invasiveness or worse prognoses [94-97] and with reduced infiltrating T cells [98], suggesting that Gal-1, produced by carcinoma and/or stromal cells surrounding the tumor, may take a part in the carcinoma immune-escape by regulation of T cell homeostasis. Here, LGALS1 is linked to carcinoma.