In another ample study on carriers of familial thrombophilia (the European Prospective Cohort on Thrombophilia [EPCOT] study), overall annual incidences of myocardial infarction and/or ischemic stroke after 20 years of age were 0.15%, 0.18Z%, and 0.15% in subjects with protein S (n=111), protein C, (n=150), and antithrombin deficiency (n=92), respectively [19]. Here, PROS1 is linked to ischemic stroke.