HPGDS and cancer: Indeed, we have recently reported that dienone cyPG, like 15d-PGJ2 and Δ12-PGJ2 induce cross-linking of the P1-1 isoform of glutathione S-transferase (GST), which is involved in cancer chemoresistance, through a mechanism likely involving cysteine residues present in different GSTP1-1 monomers [29].