IRF5 and Granuloma: Despite an approximately 4-fold higher liver parasite burden in Irf5-/- mice (Fig. 1B), the number of granulomas/inflammatory foci observed in Irf5-/- mice at d28 p.i. was reduced approximately by 77% compared with WT mice (406.7±15.7 granuloma/100 microscopic fields in WT mice vs. 92±38 granuloma/100 microscopic fields in Irf5-/- mice).