GA binds to the ATP-binding pocket of Hsp90, specifically inhibiting ATPase activity [4, 5] and therefore it has been evaluated for its antiproliferative effects in oncogenesis in vitro and in vivo with promising application as a novel anti-cancer therapy [6, 7].Several laboratories have reported activity of GA against the Hsp of Plasmodium falciparum and Brugia pahangi; however other nematodes with conserved Hsp such as Caenorhabditis elegans are not affected by GA, suggesting possible conformational heterogeneity of Hsp between species [8, 9]. Here, HSP90B2P is linked to cancer.