Using ITD-Flt3 transformed c-kit+, Sca-1+, and lineageneg (KSL) cells from conditional Survivin knockout mice as surrogates for AML stem cells and littermate controls, we identified a panel of genes that are specifically regulated by Survivin in ITD-Flt3 transformed KSL cells and known to be deregulated in human LSC. Here, BIRC5 is linked to acute myeloid leukemia.