Several reports have underlined the existence of HL cases with a lymphocyte predominant background, but differing from the prototypic description of LP-HL because of the presence of some eosinophils, sclerosis, typical H&RS cells, or aberrant phenotypic features, such as the expression of CD30 and CD15 [23, 38, 103, 107, 129]. The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.