The influence of the p53γ isoform in the setting of clinical trials such as the neoadjuvant European Organisation for Research and Treatment of Cancer (EORTC) 10994 Trial, which is testing the association between p53 mutation and taxane versus anthracycline therapy, merits consideration and would provide potential validation of the association of the p53γ isoform with p53 mutation and prognosis in the setting of a randomized, controlled trial. Here, TP53 is linked to cancer.