TP53 and cancer: Of these cases, 77% (98 of 127) were ER-positive, 62% (79 of 127) were PR-positive, 14% (17 of 119) were HER2-positive and 22% (28 of 127) had a tumour containing mutant p53. Approximately 50% (63 of 127) of the patients had axillary lymph node metastasis; tumours were grade 1 (16 cancers), grade 2 (48 cancers) or grade 3 (61 cancers), respectively.