In inflammatory lung diseases including asthma, emphysema and chronic bronchitis, serine proteases, including the Mmp8, 9 [29]Elane, cathepsin G [22] were reported to interact with structural proteins of lung cells leading to the release of neutrophil chemo-attractants which result in the recruitment of neutrophils to the site of inflammation. This evidence concerns the gene MMP8 and chronic bronchitis.