Given the close similarity between the rhesus monkey model used in this study and the diabetic state in humans, these findings suggest that aleglitazar, a dual PPARα/γ agonist, has beneficial effects on both lipid and glucose parameters and may have a therapeutic role in modifying cardiovascular risk factors and improving glycemic control in patients with T2DM. The gene discussed is PPARA; the disease is type 2 diabetes mellitus.