After 8 weeks of HFD the size of granulomas in Apoe-/- mice was smaller compared to 16 weeks of diet (12.6 ± 3.66 mm2 vs. 20.8 ± 4.3) but granulomas were still well-formed (Figure 5F) and similarly to 16 weeks, they were present in 41% of mice (table 1). The gene discussed is APOE; the disease is Granuloma.