NFE2L2 and pancreatic insulinoma: In summary, we have isolated a novel CRI-G1-RS subclone of the CRI-G1 insulinoma cellline that shows increased expression of β cell differentiation markers,reconstitution of GSIS, decreased activity of ARE/Keap1/Nrf2 pathway, and increasedvulnerability to mitochondrial dysfunction and oxidative stress compared to theparental CRI-G1-RR cells.