NFE2L2 and type 2 diabetes mellitus: What is the physiologic and pathophysiologic role of Nrf2 signaling in β cells?Oxidative stress is thought to play a significant role in the pathogenesis of bothtype 1 and type 2 diabetes; thus, the low expression level of antioxidant enzymes inβ cells – possibly reflecting the low basal activity of Nrf2 pathway, asin CRI-G1-RS cell line – renders these cells vulnerable to the oxidant-inducedcell death.