Inaddition, Aldh2 is one of key mediators of the cardiac ischemic preconditioning[33].Interestingly, a dominant negative mutation of Aldh2 (Aldh2*2), common inAsian populations, leads to alcohol intolerance and increased risk of Alzheimerdisease, particularly in ApoE4 carriers [34]; it is not currently knownwhether it also raises the risk for diabetes or other age and oxidativestress-associated diseases. Here, APOE is linked to diabetes mellitus.