In another prospective study,higher risk of Alzheimer's disease was associated not with low insulinsensitivity but with low early insulin response to oral glucose challenge, a measureof insulin release [13]; this finding, in particular, raises the possibility thatthe link between the two diseases reflects an intracellular signaling defect in apathway common to neurons and pancreatic β cells. The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.