Under these conditions all LTβR−/−, TNFR1−/−and LTα−/− mice developed terminal scrapie (LTβR−/− mice: n = 6, 291±52 dpi; TNFR1−/− mice: n = 3, 213±1 dpi; LTα−/− mice: n = 6, 251±20 dpi) (Fig. 7D–H). This evidence concerns the gene LTBR and scrapie.