CRYBB2 and ocular hypertension: Beta crystallins are expressed more highly in the retina than in other non-lens tissues [34], [35], and Cryba3 was recently reported to be restricted to astrocytes in the neural retina [36] Neuroprotection of retinal ganglion cells in a rodent model of ocular hypertension has also been reported to depend on upregulation of Crybb2.