TGFB1 and non-small cell lung carcinoma: In this study, NSCLC cell lines (A549 and H2030) underwent EMT phenotypic changes (A549-M and H2030-M cells) after chronic exposure to TGF-β1, which was consistent with decreased expression of epithelial marker concomitant with increased expression of mesenchymal markers (Fig. 1A–C; Fig. 4A).