Emerging evidence suggests that the acquisition of epithelial-to-mesenchymal transition (EMT) phenotype could be induced by Transforming Growth Factor-β (TGF-β) especially TGF-β1 among other factors, resulting in tumor invasiveness, and these EMT-type cells have been classified as cancer stem-like cells in recent studies [3]. The gene discussed is TGFB1; the disease is neoplasm.