Nevertheless, it has already been shown that inhibition of Dkk-1 by neutralizing antibodies in MM in vivo[51], [52], or in CaM cells in vitro[53], or by shRNA-mediated interference in CaP cells in vitro[54] is also able to restore bone formation suppressed by neoplastic cells. The gene discussed is DKK1; the disease is Miyoshi myopathy.