With tau and alpha-synuclein being the two most important genetic risk factors of Parkinson's disease (PD) [56] and in view of the co-precipitation of these two proteins in the pathognomonic cytoplasmic “Lewy body” inclusions [57,58], it is interesting that we found an upregulation of glyoxalase I to be the prominent response within the mouse brain transcriptome to a deficient alpha-synuclein function [59]. This evidence concerns the gene MAPT and Parkinson disease.