The patients should, moreover, also be advised to enhance the dietary intake of such antioxidant nutrients (e.g. Se and GSH, or GSH precursors, but also such plant oxidants that have been reported to have similar effects) that hopefully may help to reduce COX-2 expression and activation in the tumour cell population, tumour-associated macrophages and tumour endothelial cells. This evidence concerns the gene PTGS2 and neoplasm.