VEGFA and neoplasm: Such dietary interventions must at the same time also be expected to reduce the proangiogenic effect of VEGF released from tumour cells because they may help to reduce the rate of VEGF-induced release [203] of PGH2 from tumour endothelial cells (and in the case of EPA and DHA reduce its proangiogenic effect by blocking the thromboxane/prostaglandin endoperoxide receptor) while in the case of antioxidant nutrients also enhancing the production of antiangiogenic prostacyclin.