But in tumours where the tumour cells release much VEGF leading to enhanced expression of COX-2 in the endothelium and enhanced release of PGH from endothelial cells [203], one must expect that a reduction of the intake of AA while enhancing the intakes of EPA and DHA will also help to reduce the release of PGH2 and of total PGH from the tumour endothelial cells (even though the effect of reducing the intake of AA and enhancing the intakes of EPA and DHA is not equally large for COX-2-mediated synthesis of PGH2 in the endothelium as it is for TxA2 synthesis in the platelets). The gene discussed is PTGS2; the disease is neoplasm.