Fourth, S. bovis/gallolyticus was shown to colonize tumor lesions selectively at high titers and this colonization is located deeply inside tumor tissues rather than superficially on mucosal surfaces; this feature increases the chances of triggering the systemic, along with mucosal, immune response leading to the development of anti- S. bovis/gallolyticus IgM and IgG antibodies [40]. The gene discussed is CD40LG; the disease is neoplasm.