TNFSF10 and neoplasm: Lastly, the pro-apoptotic protein TNF-related apoptosis inducing ligand (TRAIL) which is encoded by the gene TNFSF10 was significantly reduced in 468-ΔTC compared to control (p < 0.01) (Figure 5C), consistent with the decreased tumor latency and increased tumor size observed in the in vivo studies (Figure 4A,B).