The change in the pattern of type of GLM used in MI patients during the period is likely to reflect the results of the UKPDS as well as the Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction Study 1 signaling increased survival among users of metformin in general as well as the value of early insulin treatment after a recent MI [21,28]. Here, INS is linked to acute myocardial infarction.