ACACA, RARA, NOTCH1 and NUP214 are known to form translocations in various types of hematological malignancies while many other fusion genes involve suspected oncogenes, such as RPS6KB1 (RPS6KB1-TMEM49 and RPS6KB1-SNF8) [25], GSDMB (TATDN1-GSDMB) [26] and MCF2L (LAMP1-MCF2L) [27]. The gene discussed is RPS6KB1; the disease is hematologic disorder.