PPARG and Alzheimer disease: In the present study, we assessed DHA and NPD1 abundance in control and aged 3xTg-AD mouse hippocampus and used aging human neuronal-glial (HNG) primary cells to characterize NPD1 bioactivity on: neuroinflammatory events and apoptosis; to test the mechanism of NPD1-mediated regulation of Aβ42 secretion; and to assess the significance of PPARγ in the homeostatic bioactivity of NPD1.